In 2001 the French architect Odile Decq was awarded the project of realising the museum’s expansion and works began in 2004.
In 2002, the museum was named MACRO — Museum of Contemporary Art of Rome (“Museo di Arte Contemporanea di Roma”).
In 2010, the museum reopened to the public.
Odile Decq’s intervention conferred to the Museum a dynamic system of multiple articulations and connections. The large spaces, such as the exhibition rooms (which occupy a surface area of 4350 sqm), the foyer, the auditorium and the terrace (or panoramic garden) are connected by staircases, elevators, galleries and passages which, besides offering tangential perspectives and sequential points of view, also create a dynamic and heterogeneous experience of the museum’s architecture.
During its years as the Municipal Gallery of Modern and Contemporary Art of Rome (1997–2011), the institution was headed by Giovanna Bonasegale. The building’s extension and the birth of the MACRO museum took place while Danilo Eccher was director (2001– 2008). The new wing designed by Odile Decq was inaugurated by Luca Massimo Barbero, director at the time (2008–2011), succeeded by Bartolomeo Pietromarchi (2011–2013). From 2013 to 2018, the museum was managed by two executives of the Superintendence: Giovanna Alberta Campitelli and Federica Pirani. From 2018 until 2019, the artistic direction was entrusted to Giorgio De Finis with the project MACRO Asilo.
Until 2017, the MACRO was part of the network “Musei in Comune” of the Capitoline Superintendence for Cultural Heritage.
The museum has been managed by Azienda Speciale Palaexpo, an instrumental body of Roma Capitale, Department of Cultural Growth, since 2018.